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Adoptive Immunotherapy for Cancer or Viruses

2014; Annual Reviews; Volume: 32; Issue: 1 Linguagem: Inglês

10.1146/annurev-immunol-032713-120136

1545-3278

Marcela V. Maus, Joseph A. Fraietta, Bruce L. Levine, Michael Kalos, Yangbing Zhao, Carl H. June,

Virus-based gene therapy research

Adoptive immunotherapy, or the infusion of lymphocytes, is a promising approach for the treatment of cancer and certain chronic viral infections. The application of the principles of synthetic biology to enhance T cell function has resulted in substantial increases in clinical efficacy. The primary challenge to the field is to identify tumor-specific targets to avoid off-tumor, on-target toxicity. Given recent advances in efficacy in numerous pilot trials, the next steps in clinical development will require multicenter trials to establish adoptive immunotherapy as a mainstream technology.