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BRONCHIOLOALVEOLAR LUNG CARCINOMAS: K-ras MUTATIONS ARE CONSTANT EVENTS IN THE MUCINOUS SUBTYPE

1996; Volume: 179; Issue: 3 Linguagem: Inglês

10.1002/(sici)1096-9896(199607)179

1096-9896

Antonio Marchetti, Fiamma Buttitta, Silvia Pellegrini, Antonio Chella, Gloria Bertacca, A Filardo, Vittorio Tognoni, FRANCESCA FERRELI, ELENA SIGNORINI, Carlo Alberto Angeletti, Generoso Bevilacqua,

Medical Imaging and Pathology Studies

The Journal of PathologyVolume 179, Issue 3 p. 254-259 Original Paper BRONCHIOLOALVEOLAR LUNG CARCINOMAS: K-ras MUTATIONS ARE CONSTANT EVENTS IN THE MUCINOUS SUBTYPE ANTONIO MARCHETTI, Corresponding Author ANTONIO MARCHETTI Institute of PathologyAntonio Marchetti, Institute of Pathology, University of Pisa, Via Roma 57, 56100 Pisa, ItalySearch for more papers by this authorFIAMMA BUTTITTA, FIAMMA BUTTITTA Institute of PathologySearch for more papers by this authorSILVIA PELLEGRINI, SILVIA PELLEGRINI Institute of PathologySearch for more papers by this authorANTONIO CHELLA, ANTONIO CHELLA Service of Thoracic Surgery, University of Pisa, Pisa, ItalySearch for more papers by this authorGLORIA BERTACCA, GLORIA BERTACCA Institute of PathologySearch for more papers by this authorALBERTO FILARDO, ALBERTO FILARDO Institute of PathologySearch for more papers by this authorVITTORIO TOGNONI, VITTORIO TOGNONI Institute of PathologySearch for more papers by this authorFRANCESCA FERRELI, FRANCESCA FERRELI Institute of PathologySearch for more papers by this authorELENA SIGNORINI, ELENA SIGNORINI Institute of PathologySearch for more papers by this authorCARLO ALBERTO ANGELETTI, CARLO ALBERTO ANGELETTI Service of Thoracic Surgery, University of Pisa, Pisa, ItalySearch for more papers by this authorGENEROSO BEVILACQUA, GENEROSO BEVILACQUA Institute of PathologySearch for more papers by this author ANTONIO MARCHETTI, Corresponding Author ANTONIO MARCHETTI Institute of PathologyAntonio Marchetti, Institute of Pathology, University of Pisa, Via Roma 57, 56100 Pisa, ItalySearch for more papers by this authorFIAMMA BUTTITTA, FIAMMA BUTTITTA Institute of PathologySearch for more papers by this authorSILVIA PELLEGRINI, SILVIA PELLEGRINI Institute of PathologySearch for more papers by this authorANTONIO CHELLA, ANTONIO CHELLA Service of Thoracic Surgery, University of Pisa, Pisa, ItalySearch for more papers by this authorGLORIA BERTACCA, GLORIA BERTACCA Institute of PathologySearch for more papers by this authorALBERTO FILARDO, ALBERTO FILARDO Institute of PathologySearch for more papers by this authorVITTORIO TOGNONI, VITTORIO TOGNONI Institute of PathologySearch for more papers by this authorFRANCESCA FERRELI, FRANCESCA FERRELI Institute of PathologySearch for more papers by this authorELENA SIGNORINI, ELENA SIGNORINI Institute of PathologySearch for more papers by this authorCARLO ALBERTO ANGELETTI, CARLO ALBERTO ANGELETTI Service of Thoracic Surgery, University of Pisa, Pisa, ItalySearch for more papers by this authorGENEROSO BEVILACQUA, GENEROSO BEVILACQUA Institute of PathologySearch for more papers by this author First published: July 1996 https://doi.org/10.1002/(SICI)1096-9896(199607)179:3 3.0.CO;2-JCitations: 90AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Bronchioloalveolar carcinoma (BAC) is a form of peripheral lung adenocarcinoma growing as a single layer of malignant cells along the walls of terminal airways. The existence of BAC as a separate clinico-pathological entity has been a matter of controversy, mainly because its histogenesis is uncertain and it is not easily distinguishable from conventional lung adenocarcinoma (CLA). Three subtypes of BAC have been described using histological and cytological criteria: mucinous, non-mucinous, and sclerosing. The clinical behaviour of BAC appears to be dependent on the histological subtype. The different morphological patterns and clinical outcome of the subtypes of BAC suggest that their biological behaviour may be different from one another and from CLA. This study has investigated 58 BACs (10 mucinous, 40 non-mucinous, and 8 sclerosing) and 50 control CLAs for mutations at codon 12 of the K-ras oncogene. Twenty-one (36 per cent) BACs and 13 (26 per cent) CLAs showed K-ras mutations. A clear association (P<0·0001) between K-ras mutations and the mucinous type of BAC was observed: all 10 mucinous tumours examined were scored positive for mutations in the K-ras gene, while only 9 (23 per cent) of the 40 non-mucinous and 2 (25 per cent) of the 8 sclerosing BACs were found to be positive. The frequency of ras mutations in non-mucinous BAC, sclerosing BAC, and CLA was not statistically different. Our data indicate that BACs are a heterogeneous group of lung tumours and that the mucinous form might represent a biological entity separate from both the other two BAC types and CLA. Citing Literature Volume179, Issue3July 1996Pages 254-259 RelatedInformation