Portal de Periódicos da CAPES

PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[ 11 C]O-methylreboxetine and HRRT

2009; Wiley; Volume: 64; Issue: 1 Linguagem: Inglês

10.1002/syn.20696

1098-2396

Yu‐Shin Ding, Tarun Singhal, Beata Planeta‐Wilson, Jean‐Dominique Gallezot, Nabeel Nabulsi, David Labaree, Jim Ropchan, Shannan Henry, Wendol Williams, Richard E. Carson, Alexander Neumeister, Robert T. Malison,

Neuroscience and Neuropharmacology Research

The role of the norepinephrine transporter (NET) in cocaine dependence has never been demonstrated via in vivo imaging due to the lack of suitable NET radioligands. Here we report our preliminary studies evaluting the NET in individuals with cocaine dependence (COC) in comparison to healthy controls (HC) using (S,S)-[(11)C]methylreboxetine ([(11)C]MRB), the most promising C-11 labeled positron-emission tomography (PET) radioligand for NET developed to date.