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Hypersensitivity to proton pump inhibitors: Diagnostic accuracy of skin tests compared to oral provocation test

2012; Elsevier BV; Volume: 130; Issue: 2 Linguagem: Inglês

10.1016/j.jaci.2012.04.048

1097-6825

Patrizia Bonadonna, Carla Lombardo, Oscar Bortolami, Andreas J. Bircher, Kathrin Scherer Hofmeier, A. Barbaud, Giovanni Passalacqua, Mauro Pagani,

Asthma and respiratory diseases

Proton pump inhibitors (PPIs) are widely used for the treatment of acid-related gastrointestinal diseases because they reduce the gastric acid secretion by blocking the H+/K+-ATPase. PPIs include omeprazole, lansoprazole, rabeprazole, pantoprazole, and esomeprazole. PPIs are generally well tolerated, and side effects occur in about 1% of the patients.1 Hypersensitvity reactions are also rare, but several reports have described anaphylaxis, urticaria, or asthma.2-5 The diagnosis of hypersensitivity to PPIs is difficult since PPIs are often used in combination with other drugs.