Palladium‐Catalyzed Additions of Alkenyl Epoxides to Pronucleophiles: A Synthesis of the Macrolactam Aglycone of Fluviricin B1
1997; Wiley; Volume: 36; Issue: 13-14 Linguagem: Inglês
10.1002/anie.199714861
ISSN1521-3773
AutoresBarry M. Trost, Marco Antônio Ceschi, Burkhard König,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoChirality transfer takes place during the Pd-catalyzed reaction of pronucleophiles with vinyl epoxides bearing and alkyl group at the vinyl terminus. The reaction is ideal to establish remote stereogenic centers. A synthesis of fluviricin B1 aglycone 3 from 1 and 2 illustrates the application of this new strategy for macrolactamization.
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