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Genetic loci influencing kidney function and chronic kidney disease

2010; Nature Portfolio; Volume: 42; Issue: 5 Linguagem: Inglês

10.1038/ng.566

1546-1718

John C. Chambers, Weihua Zhang, Graham M. Lord, Pim van der Harst, Debbie A. Lawlor, Joban Sehmi, Daniel P. Gale, Mark N. Wass, Kourosh R. Ahmadi, Stephan J. L. Bakker, J. Beckmann, Henk J.G. Bilo, Murielle Bochud, Matthew A. Brown, Mark J. Caulfield, John Connell, H. Terence Cook, Ioana Cotlarciuc, George Davey Smith, Ranil de Silva, Guohong Deng, Olivier Devuyst, L.D. Dikkeschei, Nada Dimković, Mark E.C. Dockrell, Anna F. Dominiczak, Shah Ebrahim, Thomas Eggermann, Martin Farrall, Luigi Ferrucci, Jürgen Floege, Nita G. Forouhi, Ron T. Gansevoort, Xijin Han, Bo Hedblad, Jaap J. Homan van der Heide, Bouke G. Hepkema, María P. Hernández-Fuentes, Elina Hyppönen, Toby Johnson, Paul E. de Jong, Nanne Kleefstra, Vasiliki Lagou, Marta Lapsley, Yun Li, Ruth J. F. Loos, Jian’an Luan, Karin Luttropp, Céline Maréchal, Olle Melander, Patricia B. Munroe, Louise Nordfors, Afshin Parsa, Leena Peltonen, Brenda W.J.H. Penninx, Esperanza Perucha, Anneli Pouta, Inga Prokopenko, Paul Roderick, Aimo Ruokonen, Nilesh J. Samani, Serena Sanna, Martin Schalling, David Schlessinger, Georg Schlieper, Marc A. Seelen, Alan R. Shuldiner, Marketa Sjögren, Johannes H. Smit, Harold Snieder, Nicole Soranzo, Timothy D. Spector, Peter Stenvinkel, Michael J.E. Sternberg, R. Swaminathan, Toshiko Tanaka, L.J. Ubink-Veltmaat, Manuela Uda, Péter Vollenweider, Chris Wallace, Dawn Waterworth, Klaus Zerres, Gérard Waeber, Nicholas J. Wareham, Patrick H. Maxwell, Mark I. McCarthy, Marjo‐Riitta Järvelin, Vincent Mooser, Gonçalo R. Abecasis, Liz Lightstone, Berthold Lausen, Gerjan Navis, Paul Elliott, Jaspal S. Kooner,

Chronic Kidney Disease and Diabetes

Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.