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Shiga Toxin‐Mediated Retrograde Delivery of a Topoisomerase I Inhibitor Prodrug

2007; Wiley; Volume: 46; Issue: 34 Linguagem: Inglês

10.1002/anie.200701270

1521-3773

Abdessamad El Alaoui, Frédéric Schmidt, Mohamed Amessou, Marianne Sarr, Didier Decaudin, Jean‐Claude Florent, Ludger Johannes,

Synthesis and bioactivity of alkaloids

A retrograde strategy: An innovative cancer-cell delivery concept exploits the naturally evolved characteristics of the Shiga toxin B-subunit (STxB) for the intracellular activation of a newly synthesized prodrug at the level of the biosynthetic/secretory pathway (see picture). Retrograde prodrug targeting allows its slow release, which should sustain the presence of the active principle in dividing tumor cells. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701270_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.