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The Efficient One‐Pot Reaction of up to Eight Components by the Union of Multicomponent Reactions

2009; Wiley; Volume: 48; Issue: 32 Linguagem: Inglês

10.1002/anie.200902683

1521-3773

Niels Elders, Dion van der Born, Loes J. D. Hendrickx, Brian J. J. Timmer, Alrik Krause, Elwin Janssen, Frans J. J. de Kanter, Eelco Ruijter, Romano V. A. Orrù,

Synthesis and biological activity

E=MCR2! The introduction of orthogonal functional groups in multicomponent reactions (MCRs) with unique solvent and functional-group compatibility enables their combination with other multicomponent reactions in one pot. The resulting novel 5- and 6CRs and an unprecedented 8CR afford very complex products in up to 80 % yields (see picture), with up to nine new bond formations and eleven diversity points in a single reaction.