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The Influence of Selection for Ethanol Withdrawal Severity on Traits Associated With Ethanol Self-Administration and Reinforcement

2010; Wiley; Volume: 35; Issue: 2 Linguagem: Inglês

10.1111/j.1530-0277.2010.01348.x

1530-0277

Matthew M. Ford, Andrea M. Fretwell, Allison M. J. Anacker, John C. Crabbe, Gregory P. Mark, Deborah A. Finn,

Receptor Mechanisms and Signaling

Alcoholism: Clinical and Experimental ResearchVolume 35, Issue 2 p. 326-337 The Influence of Selection for Ethanol Withdrawal Severity on Traits Associated With Ethanol Self-Administration and Reinforcement Matthew M. Ford, Matthew M. Ford From the Department of Behavioral Neuroscience (MMF, AMF, AMJA, JCC, GPM, DAF), Oregon Health & Science University; and Portland Alcohol Research Center (AMF, JCC, DAF), Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this authorAndrea M. Fretwell, Andrea M. Fretwell From the Department of Behavioral Neuroscience (MMF, AMF, AMJA, JCC, GPM, DAF), Oregon Health & Science University; and Portland Alcohol Research Center (AMF, JCC, DAF), Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this authorAllison M. J. Anacker, Allison M. J. Anacker From the Department of Behavioral Neuroscience (MMF, AMF, AMJA, JCC, GPM, DAF), Oregon Health & Science University; and Portland Alcohol Research Center (AMF, JCC, DAF), Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this authorJohn C. Crabbe, John C. Crabbe From the Department of Behavioral Neuroscience (MMF, AMF, AMJA, JCC, GPM, DAF), Oregon Health & Science University; and Portland Alcohol Research Center (AMF, JCC, DAF), Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this authorGregory P. Mark, Gregory P. Mark From the Department of Behavioral Neuroscience (MMF, AMF, AMJA, JCC, GPM, DAF), Oregon Health & Science University; and Portland Alcohol Research Center (AMF, JCC, DAF), Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this authorDeborah A. Finn, Deborah A. Finn From the Department of Behavioral Neuroscience (MMF, AMF, AMJA, JCC, GPM, DAF), Oregon Health & Science University; and Portland Alcohol Research Center (AMF, JCC, DAF), Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this author Matthew M. Ford, Matthew M. Ford From the Department of Behavioral Neuroscience (MMF, AMF, AMJA, JCC, GPM, DAF), Oregon Health & Science University; and Portland Alcohol Research Center (AMF, JCC, DAF), Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this authorAndrea M. Fretwell, Andrea M. Fretwell From the Department of Behavioral Neuroscience (MMF, AMF, AMJA, JCC, GPM, DAF), Oregon Health & Science University; and Portland Alcohol Research Center (AMF, JCC, DAF), Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this authorAllison M. J. Anacker, Allison M. J. Anacker From the Department of Behavioral Neuroscience (MMF, AMF, AMJA, JCC, GPM, DAF), Oregon Health & Science University; and Portland Alcohol Research Center (AMF, JCC, DAF), Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this authorJohn C. Crabbe, John C. Crabbe From the Department of Behavioral Neuroscience (MMF, AMF, AMJA, JCC, GPM, DAF), Oregon Health & Science University; and Portland Alcohol Research Center (AMF, JCC, DAF), Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this authorGregory P. Mark, Gregory P. Mark From the Department of Behavioral Neuroscience (MMF, AMF, AMJA, JCC, GPM, DAF), Oregon Health & Science University; and Portland Alcohol Research Center (AMF, JCC, DAF), Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this authorDeborah A. Finn, Deborah A. Finn From the Department of Behavioral Neuroscience (MMF, AMF, AMJA, JCC, GPM, DAF), Oregon Health & Science University; and Portland Alcohol Research Center (AMF, JCC, DAF), Veterans Affairs Medical Center, Portland, Oregon.Search for more papers by this author First published: 10 November 2010 https://doi.org/10.1111/j.1530-0277.2010.01348.xCitations: 12 Reprint requests: Matthew M. Ford, PhD, Department of Behavioral Neuroscience (L-470), Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239-3098; Tel.: 503-346-0050; Fax: 503-494-6877; E-mail: [email protected]. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Background: Several meta-analyses indicate that there is an inverse genetic correlation between ethanol preference drinking and ethanol withdrawal severity, but limited work has characterized ethanol consumption in 1 genetic animal model, the Withdrawal Seizure-Prone (WSP) and-Resistant (WSR) mouse lines selected for severe or mild ethanol withdrawal, respectively. Methods: We determined whether line differences existed in: (i) operant self-administration of ethanol during sucrose fading and under different schedules of reinforcement, followed by extinction and reinstatement of responding with conditioned cues and (ii) home cage drinking of sweetened ethanol and the development of an alcohol deprivation effect (ADE). Results: Withdrawal Seizure-Prone-1 mice consumed more ethanol than WSR-1 mice under a fixed ratio (FR)-4 schedule as ethanol was faded into the sucrose solution, but this line difference dissipated as the sucrose was faded out to yield an unadulterated 10% v/v ethanol solution. In contrast, WSR-1 mice consumed more ethanol than WSP-1 mice when a schedule was imposed that procedurally separated appetitive and consummatory behaviors. After both lines achieved the extinction criterion, reinstatement was serially evaluated following oral ethanol priming, light cue presentation, and a combination of the 2 cues. 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