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SimplePhos Monodentate Ligands: Synthesis and Application in Copper‐Catalyzed Reactions

2007; Wiley; Volume: 46; Issue: 39 Linguagem: Inglês

10.1002/anie.200702186

1521-3773

Laëtitia Palais, Igor S. Mikhel, Chloée Bournaud, Laurent Micouin, Caroline A. Falciola, Magali Vuagnoux‐d'Augustin, Stéphane Rosset, Gérald Bernardinelli, Alexandre Alexakis,

Cyclopropane Reaction Mechanisms

A simple choice: Ligands termed SimplePhos (L*), based on a chiral amino and flexible aryl groups on the phosphorus atom, induce high enantioselectivity in the copper-catalyzed conjugate addition and allylic substitution of dialkyl zinc and trialkyl aluminum reagents (see scheme; CuTC=copper thiophene carboxylate). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z702186_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.