Unprecedented asymmetric induction through configurationally stable lithium N-(α-methylbenzyl)phosphinamides. A new entry to enantiomerically pure γ-aminophosphinic acids and esters

Artigo Revisado por pares

Unprecedented asymmetric induction through configurationally stable lithium N-(α-methylbenzyl)phosphinamides. A new entry to enantiomerically pure γ-aminophosphinic acids and esters

2005; Royal Society of Chemistry; Issue: 43 Linguagem: Inglês

10.1039/b510685k

ISSN

1364-548X

Autores

Ignacio Fernández, Gloria Ruiz Gómez, Ignacio Alfonso, María José Iglesias, Fernando López Ortiz,

Tópico(s)

Asymmetric Hydrogenation and Catalysis

Resumo

The first examples of configurationally stable N-benzyl-N-phosphinoyl carbanions are described. Their applications to the synthesis of homochiral gamma-aminophosphinic acids and esters via highly enantioselective dearomatising reactions are shown.

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Unprecedented asymmetric induction through configurationally stable lithium N-(α-methylbenzyl)phosphinamides. A new entry to enantiomerically pure γ-aminophosphinic acids and esters