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Intraoperative Ketorolac Has an Opioid-Sparing Effect in Women After Diagnostic Laparoscopy but Not After Laparoscopic Tubal Ligation

1996; Lippincott Williams & Wilkins; Volume: 82; Issue: 4 Linguagem: Inglês

10.1097/00000539-199604000-00010

1526-7598

Carmen R. Green, Sujit K. Pandit, Loren Levy, Sarla P. Kothary, Alan R. Tait, M. Anthony Schork,

Inflammatory mediators and NSAID effects

Ketorolac tromethamine (Toradol Registered Trademark) is a parenteral, nonsteroidal antiinflammatory drug that is being extensively used to provide postoperative analgesia.This study evaluated whether intraoperative ketorolac would act synergistically with fentanyl to decrease postoperative analgesic requirements in outpatients undergoing gynecologic procedures. The patients studied were adult ASA physical status I or II females scheduled for diagnostic laparoscopy (DL) (n = 80) or laparoscopic tubal ligation (TL) (n = 46). Each patient received fentanyl 2 micro gram/kg intravenously (IV) before induction, followed by a standardized propofol anesthetic and 2 mL of saline or ketorolac 60 mg IV in a randomized double-blind fashion 30 min before the anticipated end of the operative procedure. Patients were assessed for postoperative pain via a 10-cm visual analog scale (VAS) (0 = no pain; 10 = severe pain) before analgesic treatment in the postanesthesia care unit (PACU). Severe postoperative pain (VAS of 5 or more) was treated with incremental doses of fentanyl, 25-50 micro gram IV by a blinded PACU nurse. Ibuprofen or acetaminophen with codeine was administered for pain control once the patient tolerated oral medications. This study showed that intraoperative ketorolac (60 mg IV) with fentanyl (2 micro gram/kg IV) administered at the induction of anesthesia resulted in significant opioid sparing and a diminution in pain in the DL sample but not in the TL sample. The analgesic regimen was also associated with a lower incidence of nausea and vomiting and resulted in earlier discharge, which was not seen after TL. These results demonstrate that pain after TL is far greater than that after DL, which suggests that these procedures should be considered separately when designing analgesic regimens. (Anesth Analg 1996;82:732-7)