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Constituintes químicos e atividade antiedematogênica de Peltodon radicans (Lamiaceae)

2008; Brazilian Chemical Society; Volume: 31; Issue: 4 Linguagem: Inglês

10.1590/s0100-40422008000400006

1678-7064

Habdel Nasser Rocha da Costa, Maria Cristina Dos‐Santos, Antônio Flávio de Carvalho Alcântara, Marilda Conceição Silva, Roberta Cabral França, Dorila Piló‐Veloso,

Bioactive Natural Diterpenoids Research

CHEMICAL CONSTITUENTS AND ANTIEDEMATOGENIC ACTIVITY OF Peltodon radicans (Lamiaceae).Most of the snakebite incidents in the Amazon region involve Bothrops atrox, whose venom presents the most potent edematogenic and necrotic activities in the genus.This work describes the studies of isolation of the chemical constituents and antiedematogenic activity of the species Peltodon radicans (Lamiaceae), which is used in the treatment of snakebites and scorpion stings in the region.The extracts presented aliphatic hydrocarbons, 3β-OH,β-amirin (1), 3β-OH,α-amirin (2), β-sitosterol (3), stigmasterol (4), ursolic acid (5), 2α,3β,19αtrihydroxy-urs-12-en-28-oic acid (tormentic acid, 6), methyl 3β-hydroxy,28-methyl-ursolate (7), sitosterol-3-O-β-D-glucopyranoside (8), and stigmasterol-3-O-β-D-glucopyranoside (9).The flower extracts presented the higher antiedematogenic activity.This is the first report on the study of the flowers, stem, and roots of this plant.