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What Are the Frequency, Distribution, and Functional Effects of Vitamin D Receptor Polymorphisms as Related to Cancer Risk?

2008; Oxford University Press; Volume: 65; Linguagem: Inglês

10.1111/j.1753-4887.2007.tb00350.x

1753-4887

Nicholas J. Rukin, Richard C. Strange,

Nutrition, Genetics, and Disease

It is clear that apart from its essential role in preventing rickets, vitamin D has a critical role in many key biochemical, immunological, and carcinogenic pathways.The varied effects of the vitamin require the vitamin D receptor gene located on chromosome 12.We discuss the structure of this gene, common single nucleotide polymorphisms (SNPs) within it, and linkage disequilibrium (LD) patterns, and relate these to known functional effects of some polymorphisms.Using prostate cancer as a paradigm, we describe our experience of gene-environment interactions in relation to disease susceptibility.