Portal de Periódicos da CAPES

X RAY TREATMENT OF TWO CASES OF OTOSOLEROSIS.

1921; Elsevier BV; Volume: 198; Issue: 5117 Linguagem: Inglês

10.1016/s0140-6736(01)34186-7

1474-547X

J. H. D. Webster,

Histiocytic Disorders and Treatments

IIL-Experiments with Smeared Virus.In this experiment the material used was a mixture of the blood and throat secretions of a scarlet fever patient.This patient, a young man of 22, had had measles and had been vaccinated ; his general health had always been good.The present illness began on March 6th, 1921, with sudden shivers and fever; scarlet fever was diagnosed by a physician, and on the 8th patient entered the Kitasato Institute Hospital.On the 10th, when I collected the material, he had erup- tion all over the body, the tongue was coated pale white, the tip was a,bright scarlet colour ; tempera- ture 37.4° C. The throat secretion was obtained after careful gargling, and the blood was taken from the median vein as in the previous cases.To determine the presence of the virus in the materials collected, the secretion was subcutaneously injected into monkey No. 148 and the blood into monkey No. 146.The former had fever of 40' C. on the 15th day, lasting for five days ; the latter had fever on the 7th day, rising on the 10th day to 39° C. with eruption over the face, especially around the eyes.These symptoms agreed with those of experimental scarlet fever in man.Throat secretion and blood were mixed and a cotton pledget, soaked in the mixture, was carefully smeared over the mucous membrane of the tonsils and throats of the children who had received prophylactic inocu- lation.As virus smeared over the mucous membrane was liable to carry infection to others, the two oldest children, who were attending school, and the youngest, who was still at the breast, were excluded from this experiment; only the boy 1. and the girl H. received the smeared material.For the next three weeks I carefully examined the temperatures, urine, and throats of the children, but there was nothing to be noted at all.Thus the inoculation completely protected the children from the disease.