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AID splice variants lack deaminase activity

2009; Elsevier BV; Volume: 113; Issue: 8 Linguagem: Inglês

10.1182/blood-2008-08-175265

1528-0020

Febe van Maldegem, Ferenc A. Scheeren, Rajni A. Jibodh, Richard J. Bende, Heinz Jacobs, Carel J.M. van Noesel,

Peptidase Inhibition and Analysis

To the editor: With particular attention we read the article by Wu et al[1][1] dealing with regulation of activation-induced cytidine deaminase (AID) by alternative splicing. We have also studied 3 alternative AID splice forms identical to the variants AID-ΔE4, AID-ΔE4a, and AID-ivs3 described by