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Phototriggering of Cell Adhesion by Caged Cyclic RGD Peptides

2008; Wiley; Volume: 47; Issue: 17 Linguagem: Inglês

10.1002/anie.200704857

1521-3773

Svea Petersen, José Marı́a Alonso, Alexandre Specht, Portia Duodu, Maurice Goeldner, Aránzazu del Campo,

Nanofabrication and Lithography Techniques

Restrained potential: A caged cyclic peptide attached to a surface is able to trigger cell attachment to the surface with spatiotemporal definition upon exposure to light (λ=351 nm). The peptide shows no integrin-binding activity in its caged form, but mediates cell adhesion effectively after irradiation (see optical microscopy image of cells on a surface irradiated through a mask in bands 100 μm in width). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z704857_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.