Portal de Periódicos da CAPES

A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia

2013; Elsevier BV; Volume: 49; Issue: 9 Linguagem: Inglês

10.1016/j.oraloncology.2013.05.011

1879-0593

Stuart J. Wong, Bruce H. Campbell, Becky Massey, D.P. Lynch, Ezra E.W. Cohen, Elizabeth A. Blair, Rebecca Selle, Julia Shklovskaya, Borko Jovanovic, Silvia Skripkauskas, Alexander Dew, Peter Kulesza, Vamsi Parimi, Raymond C. Bergan, Éva Szabó,

Salivary Gland Tumors Diagnosis and Treatment

Photodynamic therapy with aminolevulinic acid (ALA PDT) for oral leukoplakia has shown promising effects in regression of oral leukoplakia. Although ALA has been extensively studied and is an ideal photosensitizer, the optimal light dose for treatment of oral leukoplakia has not been determined. We conducted a phase I study to determine MTD and DLT of PDT in patients treated with ALA for leukoplakia. Patients with histologically confirmed oral leukoplakia received a single treatment of ALA PDT in cohorts with escalating doses of light (585 nm). Clinical, histologic, and biologic markers were assessed. Analysis of 11 participants is reported. No significant toxicity from ALA PDT was observed in patients who received ALA with a light dose of up to 4 J/cm2. One participant experienced transient grade 3 transaminase elevation due to ALA. One participant had a partial clinical response 3 months after treatment. Biologic mucosal risk markers showed no significant associations. Determination of MTD could not be accomplished within a feasible timeframe for completion of the study. ALA PDT could be safely administered with a light dose up to 4 J/cm2 and demonstrated activity. Larger studies are needed to fully elucidate the MTD and efficacy of ALA-PDT.