Role of Cell Cycle Perturbations in the Combination Therapy of Chemotherapeutic Agents and Radiation
2010; Future Medicine; Volume: 6; Issue: 9 Linguagem: Inglês
10.2217/fon.10.104
ISSN1744-8301
AutoresBea Pauwels, An Wouters, Marc Peeters, Jan B. Vermorken, Filip Lardon,
Tópico(s)Cancer Research and Treatments
ResumoThe combination of radiotherapy with chemotherapeutic agents that sensitize tumor cells to ionizing radiation has long been regarded as a promising strategy to enhance cancer therapy. Many chemotherapeutic agents interact with radiation and enhance the cytotoxic or anti-tumor effect of radiation through a number of mechanisms. These include an increase in initial radiation damage, inhibition of cellular repair, cell cycle redistribution, enhancement of apoptosis, counteracting hypoxia and overcoming accelerated repopulation. This article focuses on the role of cell cycle perturbations in the radiosensitivity of cancer cells.
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