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PD25-03 AN ELECTRONIC NOSE SYSTEM DETECTS BLADDER CANCER IN URINE SPECIMEN: FIRST RESULTS OF A PILOT STUDY

2015; Lippincott Williams & Wilkins; Volume: 193; Issue: 4S Linguagem: Inglês

10.1016/j.juro.2015.02.1652

1527-3792

Marcus Horstmann, Daniel Steinbach, Claudia Fischer, Astrid Enkelmann, Marc‐Oliver Grimm, Andreas Voß,

Advanced Chemical Sensor Technologies

You have accessJournal of UrologyBladder Cancer: Detection and Screening II1 Apr 2015PD25-03 AN ELECTRONIC NOSE SYSTEM DETECTS BLADDER CANCER IN URINE SPECIMEN: FIRST RESULTS OF A PILOT STUDY Marcus Horstmann, Daniel Steinbach, Claudia Fischer, Astrid Enkelmann, Marc-Oliver Grimm, and Andreas Voss Marcus HorstmannMarcus Horstmann , Daniel SteinbachDaniel Steinbach , Claudia FischerClaudia Fischer , Astrid EnkelmannAstrid Enkelmann , Marc-Oliver GrimmMarc-Oliver Grimm , and Andreas VossAndreas Voss View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1652AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Non invasive urine-based detection of urothelial cancer of the bladder (BC) is an important research aim. According to the literature one possible approach seems to be by olfactoric distinction. Aim of this pilot study was to evaluate the potential of our electronic nose system for the detection of BC. METHODS Fresh voided urine from 15 patients with the clinical suspicion of primary or recurrent bladder cancer and from 21 patients without BC (CON) but benign urological conditions (e.g. BPH, inflammatory disease) were randomly selected and evaluated for the presence of BC. All patients with the clinical suspicion of BC underwent transurethral resection (TURB) for histopathological verification. The used electronic nose functions based on a metal oxide gas sensor chip which includes three thin oxide layers. These thin oxide layers have different sensitivities and selectivities for various molecular types at different temperatures. On the sensor surface, a type of interaction is ensured between gas molecules of the probe and the sensor layers by changing their conductivity which is recorded over time. Data analyses were performed applying principal component analysis and discriminant analysis to classify the different patient probes. RESULTS Histopathology of transurethrally resected bladder specimen revealed in 8/15 patients urothelial cancer. Of them 5 had pTa, 2 T1 and 1 Cis only. 5/8 were low and 3/8 high grade tumours. 7/15 patients revealed no cancer in histopathology findings. Of the controls 13 had BPH, 4 inflammatory disease, 1 nephrolithiasis and 3 other benign diseases. The electronic nose detected 6/8 BC patients with BC correctly and missed 2 tumours (pTa) in the entire group of patients resulting in a sensitivity of 75%. Of the patients without BC (CON and patients with negative TURB) 24/28 were correctly diagnosed with a specificity of 86%. False positive tests were found in 4 patients of whom all 4 histopathologically had urocystitis in. Considering only the CON group all patients were correctly classified with a specificity of 100%. CONCLUSIONS The results of our present pilot study revealed the high potential of the electronic nose in the detection of BC with an overall sensitivity of 75% and specificity of 86% necessitating further investigations. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e560-e561 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Marcus Horstmann More articles by this author Daniel Steinbach More articles by this author Claudia Fischer More articles by this author Astrid Enkelmann More articles by this author Marc-Oliver Grimm More articles by this author Andreas Voss More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...