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BIBTEX RIS

The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus

2013; Oxford University Press; Volume: 68; Issue: 7 Linguagem: Inglês

10.1093/jac/dkt075

ISSN

1460-2091

Autores

Marcin G. Fraczek, Michael J. Bromley, Ahmed Buied, Caroline B. Moore, Ranjith Rajendran, Riina Rautemaa, Gordon Ramage, David W. Denning, Paul Bowyer,

Tópico(s)

Fungal Infections and Studies

Resumo

ObjectivesRecent increases in triazole resistance in Aspergillus fumigatus have been attributed primarily to target site (cyp51A) mutations. A recent survey of resistant isolates in Manchester showed that >50% of resistant isolates had no mutation in cyp51A or its promoter. We investigated the mechanisms of resistance in clinical azole-resistant isolates without cyp51A mutations.

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