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BIBTEX RIS

Human c- fms Proto-Oncogene: Comparative Analysis with an Abnormal Allele

1985; Taylor & Francis; Volume: 5; Issue: 2 Linguagem: Inglês

10.1128/mcb.5.2.422-426.1985

ISSN

1098-5549

Autores

Joseph S. Verbeek, Anton Roebroek, Aans M. W. van den Ouweland, Henri P.J. Bloemers, Wim J.M. Van de Ven,

Tópico(s)

Cancer therapeutics and mechanisms

Resumo

The organization of the human c-fms proto-oncogene has been determined and compared with an abnormal allele. The human v-fms homologous genetic sequences are dispersed discontinuously and colinearly with the viral oncogene over a DNA region of ca. 32 kilobase pairs. The abnormal c-fms locus contains a small deletion in its 3' portion. DNA sequencing analysis indicated that it was 426 base pairs in size and located in close proximity to a putative c-fms exon.

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