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Direct Electrical Detection of Biological Species

2008; Institute of Physics; Volume: 14; Issue: 1 Linguagem: Inglês

10.1149/1.2956011

2151-2051

Olivier de Sagazan, Maxime Harnois, Aurélie Girard, France Le Bihan, Anne‐Claire Salaün, Samuel Crand, Tayeb Mohammed‐Brahim,

Molecular Junctions and Nanostructures

Suspended-Gate FETs, namely SGFET, with sub-micron gap, is shown to be able to detect biological species with very high sensitivity in a large range of concentration. Examples of detection of DNA (through the DelF508 mutation of the cystic fibrosis gene that is widely disseminating in Europe and North America, and one mutation of BRCA1 gene that is the main indication of the possibility for a woman to have breast cancer) and proteins (through the transferrin that is the only carrier of iron in blood) are presented. This very sensitive electrical detection without any labelling is shown to deliver directly readable signal.