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Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin

2004; Elsevier BV; Volume: 14; Issue: 14 Linguagem: Inglês

10.1016/j.bmcl.2004.05.017

1464-3405

S. Chandrasekhar, V. Jagadeshwar, Ch. Narsihmulu, M. Sarangapani, D. R. Krishna, J. Vidyasagar, Dolly Vijay, G. Narahari Sastry,

Chemical synthesis and alkaloids

A straight forward entry into nine membered B ring of eleutherobin as oxy analog and its cyctotoxic properties on HBL cell lines is described. Molecular modeling studies were carried out to ascertain the binding of the model compound to the active site of beta-tubulin.