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An 18-month follow-up study after randomized treatment of phimosis in boys with topical steroid versus placebo

2005; Taylor & Francis; Volume: 39; Issue: 1 Linguagem: Inglês

10.1080/00365590410002519

1651-2065

Lars Lund, K. H. Wai, L. M. Mui, Chung‐Kwong Yeung,

Urological Disorders and Treatments

Abstract Objective To evaluate the treatment of phimosis using topical steroid. Material and methods This was a follow-up study after a prospective, randomized, double-blind study. A total of 137 boys with phimosis were randomly assigned to either betamethasone treatment or placebo for 4 weeks, with application of the cream twice daily. Non-responders to treatment were offered steroid treatment for a further 4 weeks. All patients were invited to a follow-up examination after 18 months. Results The mean pre-treatment phimosis grades in the steroid and control groups were 5.08±0.66 and 4.97±0.70, respectively. At the 4-week follow-up, 49 boys (74%) in the steroid group were cured, compared to only 31 (44%) in the control group. Fourteen boys were circumcised after another 4 weeks of treatment; 43 of the remaining 57 boys (17 in the steroid group; 40 in the control group) had been cured. After a total of 92 boys took part in the 18-month follow-up study: 79 had been cured and 13 had suffered a relapse. Twenty-six patients did not took part in the follow-up investigation. No side-effects were noted. Conclusions When treatment is necessary for phimosis, we recommend application of topical steroid as first-line treatment because surgery can then be avoided in 85% of cases. This first randomized, double-blind, follow-up study shows that the treatment effect persists for at least 18 months.Conservative treatmentphimosistopical steroid