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Carbazole Alkaloids III

1991; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-7091-9119-4_2

2192-4309

D. P. CHAKRABORTY, Shyamali Roy,

Chemical synthesis and alkaloids

Major developments in the chemistry of carbazoles until 1960 arose mainly as a result of their use in the dye stuff and polymer industries although carbazole itself (1) was discovered in coal tar in 1872 by Graebe and Glazer (53). Since the report of the first carbazole alkaloid murrayanine (2) from Murraya koeinigii Spreng and the antibiotic properties of these alkaloids in 1965 by Chakraborty et al. (22, 31), there has been wider interest on the structure, synthesis and biochemical properties of these compounds. At present more than one hundred alkaloids are known and various biochemical and medicinal properties of this group of compounds have been investigated. Several reviews relating to carbazole alkaloids have appeared since 1971 (67,18, 19, 20, 56, 11). The present review relates to work reported after the previous review (11) and earlier results not included therein.