Portal de Periódicos da CAPES

Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein

2001; Elsevier BV; Volume: 26; Issue: 6 Linguagem: Inglês

10.1016/s0968-0004(01)01846-1

1362-4326

Stefan T. Arold, Andreas S. Baur,

Protein Structure and Dynamics

The Nef protein of the human immunodeficiency virus is as important for disease progression as it is perplexing in its plethora of target molecules and functions. In this article, it is proposed that the complex biology of Nef is regulated through conformational changes of the protein that are triggered by cellular location and specific interactions as Nef traffics through the infected cell.