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The Surprising Discovery That TGFβ Specifically Induces the IgA Class Switch

2009; American Association of Immunologists; Volume: 182; Issue: 1 Linguagem: Inglês

10.4049/jimmunol.182.1.5

1550-6606

Janet Stavnezer, Joonsoo Kang,

Immune Cell Function and Interaction

The two Pillars of Immunology articles in this issue ([1][1], [2][2]) were the first to demonstrate that IgA switching is induced by TGFβ. In 1989, when these two important papers were published, it was known that IL-4 directs LPS-activated B cells to switch to IgG1 and IgE ([3][3], [4][4], [5][5