Bioactivity-based screening of antibiotics and hormones
2009; Elsevier BV; Volume: 1216; Issue: 46 Linguagem: Inglês
10.1016/j.chroma.2009.03.045
ISSN1873-3778
AutoresToine F. H. Bovee, M.G. Pikkemaat,
Tópico(s)Metabolomics and Mass Spectrometry Studies
ResumoBioactivity-based screening methods are relatively cheap, quick and easy to use tools. Especially with respect to antimicrobial residues and compounds with hormonal activity, they form a very cost-effective alternative to physical chemical methods in large-scale surveillance and monitoring programs, where their main purpose is to identify samples that require additional chemical confirmation. A major advantage is their intrinsic capability to detect unknown compounds and new hazards. This review shows an overview of the available methods and their potential and limitations for regulatory control.
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