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Chronic Kidney Disease After Nephrectomy in Patients with Small Renal Masses: A Retrospective Observational Analysis

2012; Elsevier BV; Volume: 62; Issue: 4 Linguagem: Inglês

10.1016/j.eururo.2012.03.051

1873-7560

Maxine Sun, Marco Bianchi, Jens Hansen, Quoc‐Dien Trinh, Firas Abdollah, Zhe Tian, Jesse D. Sammon, Shahrokh F. Shariat, Markus Graefen, Francesco Montorsi, Paul Perrotte, Pierre I. Karakiewicz,

Chronic Kidney Disease and Diabetes

Chronic kidney disease (CKD) is a worldwide health threat associated with increased cardiovascular disease and mortality. To examine postoperative CKD in patients with small renal masses (SRMs) treated with partial nephrectomy (PN) or radical nephrectomy (RN). A US National Cancer Institute Surveillance Epidemiology and End Results (SEER)–Medicare-linked retrospective cohort of 4633 T1aN0M0 renal cell carcinoma (RCC) patients who underwent PN or RN. The primary outcome of interest was the onset of CKD stage ≥3. Secondary end points comprised acute renal failure (ARF), chronic renal insufficiency (CRI), anemia in CKD, and end-stage renal disease (ESRD). Kaplan-Meier and Cox regression analyses were performed. Postpropensity matching resulted in 840 RN and PN patients. In multivariable analyses, RN patients were 1.9-, 1.4-, 1.8-, and 1.8-fold more likely to have an occurrence of CKD, ARF, CRI, and anemia in CKD, respectively (all p ≤ 0.004). The risk of ESRD between treatment groups failed to achieve statistical significance (p = 0.06). PN is associated with more favorable postoperative renal function outcomes relative to RN in the setting of SRMs.