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The Effects of QuikClot Combat Gauze and Movement on Hemorrhage Control in a Porcine Model

2012; Oxford University Press; Volume: 177; Issue: 12 Linguagem: Inglês

10.7205/milmed-d-12-00165

1930-613X

Brian Gegel, James Burgert, John Gasko, C.G.H. Campbell, Mark G. Martens, Joseph Keck, Harmony R. Reynolds, Michael Loughren, Don Johnson,

Surgical Sutures and Adhesives

The purpose of this study was twofold: (1) to examine the effectiveness of QuikClot Combat Gauze (QCG) compared to a control group and (2) investigate the effect of movement on hemorrhage control when QCG is employed. This was a prospective, experimental design employing an established porcine model of uncontrolled hemorrhage. The minimum number of animals (n = 11 per group) was used to obtain a statistically valid result. There were no statistically significant differences between the groups (p > 0.05) indicating that the groups were equivalent on the following parameters: activating clotting time, the subject weights, core body temperatures, amount of 1 minute hemorrhage, arterial blood pressures, and the amount and percentage of total blood volume. There were significant differences in the amount of hemorrhage (p = 0.018) and the number of movements (p = 0.000) between the QCG and control. QCG is statistically and clinically superior at controlling hemorrhage compared to the standard pressure dressing control group. Furthermore, it produces a more robust clot that can withstand significant movement. In conclusion, QCG is an effective hemostatic agent for use in civilian and military trauma management.