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Association of polymorphisms in IL6 gene promoter region with type 1 diabetes and increased albumin‐to‐creatinine ratio

2014; Wiley; Volume: 31; Issue: 5 Linguagem: Inglês

10.1002/dmrr.2621

1520-7560

Marcela Abbott Galvão Ururahy, Karla Simone Costa de Souza, Yonara Monique da Costa Oliveira, Melina Bezerra Loureiro, Heglayne Pereira Vital da Silva, Francisco Paulo Freire‐Neto, João Felipe Bezerra, André Ducati Luchessi, Sonia Q. Doi, Rosário Dominguez Crespo Hirata, Maria das Graças Almeida, Ricardo Fernando Arrais, Mário Hiroyuki Hirata, Adriana Augusto de Rezende,

Diabetes Treatment and Management

Abstract Background Pro‐inflammatory cytokines, such as interleukin‐6 (IL‐6), have been considered as key factors in type 1 diabetes mellitus (T1DM) and diabetic nephropathy, thus, our aim was to investigate the association of IL6 ‐174G>C (rs1800795) and ‐634C>G (rs1800796) polymorphisms with T1DM susceptibility and diabetic nephropathy. Methods These polymorphisms were analyzed in 144 children and adolescents with T1DM and 173 normoglycemic control subjects. Glycemic control, laboratory parameters of kidney function and serum lipids were evaluated. By studying only T1DM patients, we evaluated the polymorphisms associated with relevant biochemical parameters in various genetic models. Results Type 1 diabetes mellitus patients showed poor glycemic control and albumin‐to‐creatinine ratio, total cholesterol and LDL‐cholesterol levels increased when compared with normoglycemic subjects ( p < 0.001, p = 0.004 and p < 0.001, respectively). IL6 ‐174C allele was associated with an increased risk of developing T1DM (OR = 1.53, CI = 1.01‐2.31, p = 0.044). In the T1DM group, IL6 ‐174CC carriers showed higher concentrations of glycated hemoglobin ( p = 0.029), albumin‐to‐creatinine ratio ( p = 0.021), total cholesterol ( p = 0.010), and LDL‐cholesterol ( p = 0.002), when compared with GG+GC carriers. No association was found for the IL6 ‐634C>G polymorphism. Conclusions These results suggest that IL6 ‐174G>C may contribute to T1DM and increased albumin‐to‐creatinine ratio as well as to poor glycemic control and hyperlipidemia. Copyright © 2014 John Wiley & Sons, Ltd.