Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target
2013; Oxford University Press; Volume: 154; Issue: 1 Linguagem: Inglês
10.1093/jb/mvt037
ISSN1756-2651
AutoresE.O. Balogun, D.K. Inaoka, T. Shiba, Yasutoshi Kido, Takeshi Nara, Takashi Aoki, Teruki Honma, A. Tanaka, Masayuki Inoue, Shigeru Matsuoka, Paul A.M. Michels, Shigeharu Harada, Kiyoshi Kita,
Tópico(s)Toxin Mechanisms and Immunotoxins
ResumoJournal Article Biochemical characterization of highly active Trypanosoma brucei gambiense glycerol kinase, a promising drug target Get access Emmanuel Oluwadare Balogun, Emmanuel Oluwadare Balogun 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Daniel Ken Inaoka, Daniel Ken Inaoka 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Tomoo Shiba, Tomoo Shiba 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Yasutoshi Kido, Yasutoshi Kido 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Takeshi Nara, Takeshi Nara 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Takashi Aoki, Takashi Aoki 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Teruki Honma, Teruki Honma 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Akiko Tanaka, Akiko Tanaka 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Masayuki Inoue, Masayuki Inoue 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Shigeru Matsuoka, Shigeru Matsuoka 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Paul AM. Michels, Paul AM. Michels 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar Shigeharu Harada, Shigeharu Harada * 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium *Shigeharu Harada, Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan. Tel: +81-7-5724-7541, Fax: +81-7-5724-7541, email: harada@kit.ac.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar Kiyoshi Kita Kiyoshi Kita 1Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; 2Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan; 3Department of Biochemistry, Ahmadu Bello University, Zaria 2222, Nigeria; 4Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine, Tokyo 113-8421, Japan; 5Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Japan; 6Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; and 7Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, B-1200 Brussels, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 154, Issue 1, July 2013, Pages 77–84, https://doi.org/10.1093/jb/mvt037 Published: 25 April 2013 Article history Received: 06 March 2013 Accepted: 31 March 2013 Published: 25 April 2013
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