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Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

2003; American Association for the Advancement of Science; Volume: 302; Issue: 5647 Linguagem: Inglês

10.1126/science.1090148

1095-9203

Erika L. Pearce, Alan C. Mullen, Gislâine A. Martins, Connie M. Krawczyk, Anne S. Hutchins, Valerie P. Zediak, Monica Banica, Catherine B. DiCioccio, Darrick A. Gross, Chai‐An Mao, Hao Shen, Nezih Cereb, Soo Young Yang, Tullia Lindsten, Janet Rossant, Christopher A. Hunter, Steven L. Reiner,

T-cell and B-cell Immunology

Activated CD8 + T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8 + T cells. We now show that Eomesodermin ( Eomes ), a paralogue of T-bet , is induced in effector CD8 + T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8 + T cells, including interferon-γ (IFN-γ), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8 + T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.