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6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-γ activators

2005; Elsevier BV; Volume: 15; Issue: 14 Linguagem: Inglês

10.1016/j.bmcl.2005.05.031

1464-3405

Ashoke Sharon, Ramendra Pratap, Rit Vatsyayan, P.R. Maulik, Uma Roy, Atul Goel, Vishnu Ji Ram,

Click Chemistry and Applications

Various 6-aryl-3-cyano/methoxycarbonyl-4-methylsulfanyl-2H-pyran-2-ones have been synthesized as a potential substitute of 2,4-thiazolidinedione head group to express potent PPAR-γ transactivation response. Some of the screened compounds have shown promising PPAR-γ agonistic activity.