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Studies in Myasthenia Gravis

1965; American College of Physicians; Volume: 63; Issue: 3 Linguagem: Inglês

10.7326/0003-4819-63-3-416

1539-3704

Peter Kornfeld,

Thyroid and Parathyroid Surgery

Article1 September 1965Studies in Myasthenia GravisImmunologic Response in Thymectomized and Nonthymectomized PatientsPETER KORNFELD, M.D., F.A.C.P., SHEPPARD SIEGAL, M.D., F.A.C.P., LEE BURNETT WEINER, PH.D., KERMIT E. OSSERMAN, M.D., F.A.C.P.PETER KORNFELD, M.D., F.A.C.P.Search for more papers by this author, SHEPPARD SIEGAL, M.D., F.A.C.P.Search for more papers by this author, LEE BURNETT WEINER, PH.D.Search for more papers by this author, KERMIT E. OSSERMAN, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-3-416 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIt has recently been suggested that myasthenia gravis may be an autoimmune disease (1-3). This hypothesis is supported by [1] the presence of abnormal antibodies in myasthenic patients such as serum globulins reacting with skeletal, cardiac muscle, and epithelial cells of the thymus, antinuclear factors, and thyroglobulin antibodies (4-7); [2] correlations between fluctuations in serum complement levels and clinical course of the disease (1); [3] passage of a possible transplacental factor from myasthenic mother to newborn baby (8); [4] high incidence of thymoma and thymic hyperplasia with and without germinal centers (9). The literature contains many reports on the coexistence...References1. NASTUKPLESCIAOSSERMAN WLOJKE: Changes in serum complement activity in patients with myasthenia gravis. Proc. Soc. Exp. Biol. Med. 105: 177, 1960. CrossrefMedlineGoogle Scholar2. SIMPSON JA: Myasthenia gravis: a new hypothesis. Scot. Med. J. 5: 419, 1960. CrossrefGoogle Scholar3. OSSERMAN KE: Myasthenia gravis: an autoimmune mechanism? Bull. Sch. Med. Univ. Maryland 47: 1, 1962. MedlineGoogle Scholar4. STRAUSSSEEGALHSUBURKHOLDERNASTUKOSSERMAN AJBCKCPMWLKE: Immunofluorescence demonstration of a muscle binding complement-fixing serum globulin in myasthenia gravis. Proc. Soc. Exp. Biol. Med. 105: 184, 1960. CrossrefGoogle Scholar5. BEUTNERWITEBSKYRICKENADLER EHEDRH: Sudies on autoantibodies in myasthenia gravis. JAMA 182: 46, 1962. MedlineGoogle Scholar6. FELTKAMPVAN DER GELDOOSTERHUIS TEHHJ: Antinuclear factor in myasthenia gravis. Lancet 1: 667, 1963. CrossrefMedlineGoogle Scholar7. ADNERSHERMANISESCHWABDAMESHEK MMJDCRW: Myasthenia gravis, the thymus, auto-immunity (abstract). Fed. Proc. 23: 342 (Part I), 1964. Google Scholar8. OSSERMAN KE: Myasthenia Gravis. Grune & Stratton, New York and London, 1958. Google Scholar9. CASTLEMANNORRIS BEH: Pathology of the thymus in myasthenia gravis. Medicine (Balt.) 28: 27, 1949. CrossrefMedlineGoogle Scholar10. JACOXMORGANVAUGHINHANSHAW RFESJHJB: As quoted in Bull. Rheum. Dis. 14: 321, 1963. Google Scholar11. GAFNIMICHAELIHELLER JDH: Idiopathic acquired agammaglobulinemia associated with thymoma. New Eng. J. Med. 263: 536, 1960. CrossrefMedlineGoogle Scholar12. BIRCHCOOKEDREWLONDONMACKANZIEMILNE CAKBCEDRDHMD: Hyperglobulinemic purpura due to thymic tumor. Lancet 1: 693, 1964. CrossrefMedlineGoogle Scholar13. FUNKHOUSER JW: Thymoma associated with myocarditis and the L. E. cell phenomenon. New Eng. J. Med. 264: 34, 1961. CrossrefMedlineGoogle Scholar14. GALBRAITHSUMMERSKILLMURRAY RFWHJ: Systemic lupus erythematosus, cirrhosis and ulcerative colitis after thymectomy for myasthenia gravis. New Eng. J. Med. 270: 229, 1964. CrossrefMedlineGoogle Scholar15. WILMERSRUSSELL MJPA: Autoimmune hemolytic anemia in an infant treated by thymectomy. Lancet 2: 915, 1963. CrossrefMedlineGoogle Scholar16. HAVARDSCOTT CWRB: Thymic tumor and erythroblastic aplasia. Brit. J. Haemat. 6: 178, 1960. CrossrefMedlineGoogle Scholar17. FISHERBEYER ERFD: Thymoma and hemopoietic insufficiency. Arch. Intern. Med. (Chicago) 103: 95, 1959. CrossrefGoogle Scholar18. KLEINGOTTLIEBMONESAPPELOSSERMAN JJAJRJSHKE: Thymoma and polymyositis. Arch. Intern. Med. (Chicago) 113: 142, 1964. CrossrefMedlineGoogle Scholar19. VIETSSCHWAB HRRS: Thymectomy for Myasthenia Gravis. Charles C Thomas, Springfield, Ill., 1960. Google Scholar20. OSOBAMILLER DJF: Lymphoid tissues and immune responses of neonatally thymectomized mice bearing thymus tissue in millipore diffusion chambers. J. Exp. Med. 119: 177, 1964. CrossrefMedlineGoogle Scholar21. MILLERDOAKCROSS JFSMAM: Role of the thymus in the recovery of the immune mechanism in the irradiated adult mouse. Proc. Soc. Exp. Biol. Med. 112: 785, 1963. CrossrefGoogle Scholar22. LAWRENCE HS: Cellular Aspects of Immunity. Ciba Symposium, Boston, 1959. Google Scholar23. OSSERMANKORNFELDCOHENGENKINSMENDELOWGOLDBERGWINDSLEYKAPLAN KEPEGHHHLI: Studies in myasthenia gravis. Review of 282 cases at The Mount Sinai Hospitalx, New York City Arch. Intern. Med. (Chicago) 102: 72, 1958. CrossrefGoogle Scholar24. TOPLEYWILSON WWGS: Principles of Bacteriology and Immunity, Vol. II, 4th ed. The Williams & Wilkins Co., Baltimore, 1955. Google Scholar25. U. S. ARMY MEDICAL SCHOOL: Immunization to Typhoid Fever: Amer. J. Hyg. Monograph 17. The Johns Hopkins Press, Baltimore, 1941, pp. 122-176. Google Scholar26. KORNFELD P: Serum proteins in myasthenia gravis. JAMA 190: 463, 1964. CrossrefMedlineGoogle Scholar27. OSSERMANWEINER KELB: Studies in myasthenia gravis: immunofluorescent tagging of muscle striation with antibody from serums of 256 myasthenic patients. Conference on autoimmunity. Ann. NY Acad. Sci., 124: 730, 1965. CrossrefMedlineGoogle Scholar28. ADNERSHERMANISESCHWABDAMESHEK MMJDCRW: Immunologic survey of patients with myasthenia gravis. New Eng. J. Med. 271: 1327, 1964. CrossrefMedlineGoogle Scholar29. ZOLLINGERLINDEMFILLERCORSONWILSON RMMCRMJMRE: Effect of thymectomy on skin homograft survival in children. New Eng. J. Med. 270, 707, 1964. CrossrefMedlineGoogle Scholar30. FICHTELIUSLAURELLPHILIPSSON KEML: The influence of thymectomy on antibody formation. Acta Path. Microbiol. Scand. 51: 81, 1961. CrossrefMedlineGoogle Scholar31. ARCHERPIERCE OKJG: Role of thymus in development of the immune response. Fed. Proc. 20: 26, 1961. Google Scholar32. JANKOVICWAKSMANARNASON BDBHBG: Role of the thymus in immune reactions in rats. I. The immunologic response to bovine serum albumin (antibody formation, Arthus reactivity, and delayed hypersensitivity) in rats thymectomized or splenectomized at various times after birth. J. Exp. Med. 116: 159, 1962. MedlineGoogle Scholar33. ARNASONJANKOVICWAKSMANWENNERSTEN BGBDBHC: Role of the thymus in immune reactions in rats. II. Suppressive effect of thymectomy at birth or reactions of delayed (cellular) hypersensitivity and the circulating small lymphocyte. Ibid., p. 177. Google Scholar34. WAKSMANARNASONJANKOVIC BHBGBD: Role of the thymus in immune reactions in rats. III. Changes in the lymphoid organ of thymectomized rats. Ibid., p. 187. Google Scholar35. MILLEROSOBA JFD: The role of the thymus in the origin of immunological competence appearing in the immunologically competent cells, in The Immunologically Competent Cell. Its Nature and Origin. BURNET, SIR MACFARLANE (Ciba Study Group No. 16). Little, Brown and Co., Boston, 1963, pp. 62-76. Google Scholar36. STRAUSSVAN DER GELDKEMPEXUMGOODMAN AJHWPGEDHC: Reactivity of serum γ-globulins from myasthenia gravis patients against skeletal muscle striations: specificity, incidence and association with thymic pathology. Conference on Auto-Immunity. Ann. NY Acad. Sci. 124: 744, 1965. CrossrefMedlineGoogle Scholar37. OSSERMANWEINER KELB: Studies in myasthenia gravis: changes in demonstration of antibody immunofluorescence correlated with clinical course. Fed. Proc. 24: 694 (Part 1) 1965. Google Scholar38. STRAUSSVAN DER GELDSMITHMCFARLINBARLOW AJHWCWDM: Further studies on the specificity of autoimmune phenomenon associated with myasthenia gravis and considerations of possible pathogenic implications. Conference on Myasthenia Gravis. Ann. NY Acad. Sci. In press. Google Scholar39. WEINEROSSERMAN LBKE: Correlation of presence of immunofluorescence in serums with clinical findings in myasthenia gravis. Conference on Myasthenia Gravis. Ann. N. Y. Acad. Sci. Google Scholar40. GOODDALMASSOMARTINEZARCHERPIERCEPAPERMASTER RAAPCOKJCBW: The role of the thymus in development of immunologic capacity in rabbits and mice. J. Exp. Med. 116: 773, 1962. CrossrefMedlineGoogle Scholar41. SOKALPRIMKIRIOS JEN: The delayed skin test response in Hodgkin's disease and lymphosarcoma. Effect of disease activity. Cancer 14: 597, 1961. CrossrefGoogle Scholar42. U. S. Department of Health, Education, and Welfare, Public Health Service: Tuberculosis Chart Series, Washington, D. C., 1957. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: PETER KORNFELD, M.D., F.A.C.P.; SHEPPARD SIEGAL, M.D., F.A.C.P.; LEE BURNETT WEINER, PH.D.; KERMIT E. OSSERMAN, M.D., F.A.C.P.From the Department of Medicine, Myasthenia Gravis Clinic and Research Laboratory, The Mount Sinai Hospital, New York, N. Y.This work was supported by research grant NB 04087-02 from the National Institute of Neurological Diseases and Blindness, U. S. Public Health Service, Bethesda, Md., and grant 15/181/4 of the World Health Organization.Requests for reprints should be addressed to Peter Kornfeld, M.D., Myasthenia Gravis Research Laboratory, The Mount Sinai Hospital, 5th Ave. and 100th St. New York, N. Y. 10029. 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KOPP, M.D., JERRY S. TRIER, M.D., E. RICHARD STIEHM, M.D., PARVIZ FOROOZAN, M.D.Studies in myasthenia gravisDiscussion 1 September 1965Volume 63, Issue 3Page: 416-428KeywordsAntibodiesHospital medicineMyasthenia gravisResearch grantsResearch laboratoriesStem cellsThymomaThymusThyroglobulinThyroid ePublished: 1 December 2008 Issue Published: 1 September 1965 PDF downloadLoading ...