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Overview and Findings from the Religious Orders Study

2012; Bentham Science Publishers; Volume: 9; Issue: 6 Linguagem: Inglês

10.2174/156720512801322573

1875-5828

David A. Bennett, Julie A. Schneider, Zoe Arvanitakis, R. J. Wilson,

Frailty in Older Adults

The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and Alzheimer’s disease (AD). In this manuscript, we summarize the study methods including the study design and describe the clinical evaluation, assessment of risk factors, collection of ante-mortem biological specimens, brain autopsy and collection of selected postmortem data. The results: 1) review the relation of neuropathologic indices to clinical diagnoses and cognition proximate to death; 2) examine the relation of risk factors to clinical outcomes; 3) examine the relation of risk factors to measures of neuropathology; and 4) summarize additional study findings. We then discuss and contextualize the study findings. Keywords: Religious Orders Study, Dementia, Alzheimer's Disease, Cognitive Function, Epidemiology, Clinical-pathologic Study, Neuropathology, Cohort