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On the Structure of the T-cell Receptor for Antigen

1977; Cold Spring Harbor Laboratory Press; Volume: 41; Linguagem: Inglês

10.1101/sqb.1977.041.01.034

1943-4456

Ulrich Krawinkel, Matthias Cramer, Claudia Berek, Günter J. Hämmerling, Samuel J. Black, Klaus Rajewsky, Klaus Eichmann,

Immune Cell Function and Interaction

The antigen receptor of B lymphocytes is a classical antibody molecule whose specificity is determined by six hypervariable regions, three of which belong to the light chain and three to the heavy chain. The antigen receptor of T lymphocytes, on the other hand, is a molecule of thus far unknown structure that does not appear to be of the conventional immunoglobulin (Ig) design. In this paper, the problem of the molecular nature of the T-cell receptor is discussed on the basis of two lines of experimental work. The first is the idiotypic analysis of the functional antigen receptor of T helper cells. The second consists of an approach to isolate antigen receptors from the T-cell surface and to characterize them directly.