Antibiotic and Hemolytic Activity of a β 2 /β 3 Peptide Capable of Folding into a 12/10‐Helical Secondary Structure
2003; Wiley; Volume: 4; Issue: 12 Linguagem: Inglês
10.1002/cbic.200300698
ISSN1439-7633
AutoresPer I. Arvidsson, Neil S. Ryder, H. Weiss, Gerhard Groß, Olivier Kretz, Ralph Woessner, Dieter Seebàch,
Tópico(s)RNA and protein synthesis mechanisms
ResumoActive peptide helices : The β‐nonapeptide H‐β 3 HPhe‐β 2 HVal‐β 3 HPhe‐β 2 HLeu‐β 3 HLys‐β 2 HLeu‐β 3 HLys‐β 2 HLeu‐β 3 HPhe‐OH with alternating β 2 ‐ and β 3 ‐amino‐acid residues has been tested for antibiotic and hemolytic activities. This represents the first case of biomimetic activity of a “mixed” β 3 /β 2 ‐peptide.
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