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lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs

2014; Oxford University Press; Volume: 43; Issue: D1 Linguagem: Inglês

10.1093/nar/gku988

1362-4962

Xiu Cheng Quek, Daniel Thomson, Jesper L.V. Mååg, Nenad Bartoniček, Bethany Signal, Michael B. Clark, Brian Gloss, Marcel E. Dinger,

RNA modifications and cancer

Despite the prevalence of long noncoding RNA (lncRNA) genes in eukaryotic genomes, only a small proportion have been examined for biological function. lncRNAdb, available at http://lncrnadb.org, provides users with a comprehensive, manually curated reference database of 287 eukaryotic lncRNAs that have been described independently in the scientific literature. In addition to capturing a great proportion of the recent literature describing functions for individual lncRNAs, lncRNAdb now offers an improved user interface enabling greater accessibility to sequence information, expression data and the literature. The new features in lncRNAdb include the integration of Illumina Body Atlas expression profiles, nucleotide sequence information, a BLAST search tool and easy export of content via direct download or a REST API. lncRNAdb is now endorsed by RNAcentral and is in compliance with the International Nucleotide Sequence Database Collaboration.