Synthesis of glycosylated β-amino acids as new class of antitubercular agents
2002; Elsevier BV; Volume: 37; Issue: 9 Linguagem: Inglês
10.1016/s0223-5234(02)01398-3
ISSN1768-3254
AutoresRama P. Tripathi, Rama P. Tripathi, Vinod K. Tiwari, Laxmi Bala, Sudhir Sinha, Anil Srivastava, Arvind K. Srivastava, Brahm S. Srivastava,
Tópico(s)Tuberculosis Research and Epidemiology
ResumoA series of glycosylated β-amino acids was prepared and evaluated against Mycobacterium tuberculosis, M. avium, M. fortuitum and M. smegmatis. The compounds were designed to mimic the enzyme d-alanine racemase and glycosyl transferase involved in the biosynthesis of essential cell wall peptidoglycan and arabinogalactan. Though most of the compounds exhibited little activity, however, one showed significant activity against all the strains in cell culture and activity was confirmed by Bactec method.
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