Produção Nacional
Revisado por pares
Burkholderia pseudomallei Antibodies in Individuals Living in Endemic Regions in Northeastern Brazil
2011; American Society of Tropical Medicine and Hygiene; Volume: 84; Issue: 2 Linguagem: Inglês
10.4269/ajtmh.2011.10-0220
ISSN1476-1645
AutoresDionne Bezerra Rolim, Dina Cortez Feitosa Lima Vilar, Luciano Pamplona de Góes Cavalcanti, Liara B. N. Freitas, Timothy J. J. Inglis, Jorge Luíz Nobre Rodrigues, Aparecida Tiemi Nagao‐Dias,
Tópico(s)Corporate Taxation and Avoidance
ResumoA seroepidemiological investigation was conducted among the population of two municipalities in Northeastern Brazil. Immunoglobulin M (IgM) and IgG antibodies to Burkholderia pseudomallei were positive in 51.27% (161 in 317 samples) and 58.49% (186), respectively. IgM titers were higher in children than in adults. On the contrary, IgG increased progressively with age. We observed a significant association between agricultural occupation and raised IgM titers (P < 0.005) and IgG titers (P < 0.001), and between construction workers and raised IgG titers (P = 0.005). Antibody IgG avidities did not correlate with age. The highest titers of antibodies (1/800) showed the highest antibody avidity indexes (P < 0.01). Most of the serum samples recognized 45-kDa and 200-kDa bands by IgG1 and IgG2 subclasses. Our study showed a high seropositivity among individuals living in endemic regions of the state of Ceará, and highlights the need for further surveillance close to water courses such as dams and rivers in Northeastern Brazil.
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