How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function
2013; National Academy of Sciences; Volume: 110; Issue: 42 Linguagem: Inglês
10.1073/pnas.1300118110
ISSN1091-6490
AutoresLisandro H. Otero, A. Rojas-Altuve, Leticia I. Llarrull, César Carrasco‐López, Malika Kumarasiri, Elena Lastochkin, Jennifer Fishovitz, M. Michele Dawley, Dušan Hesek, Mijoon Lee, Jarrod W. Johnson, Jed F. Fisher, Mayland Chang, Shahriar Mobashery, J.A. Hermoso,
Tópico(s)Microbial Natural Products and Biosynthesis
ResumoSignificance Penicillin binding protein 2a imparts to the human pathogen Staphylococcus aureus resistance to β-lactam antibiotics. Our structural characterization of the allosteric basis governing its resistance mechanism identifies a basis for the design of new antibacterials that can both activate and inhibit this key resistance enzyme.
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