Portal de Periódicos da CAPES

Chromosomal aberrations and their prognostic value in a series of 174 untreated patients with Waldenstrom's macroglobulinemia

2012; Ferrata Storti Foundation; Volume: 98; Issue: 4 Linguagem: Inglês

10.3324/haematol.2012.070458

1592-8721

Florence Nguyen‐Khac, Jérôme Lambert, Élise Chapiro, Aurore Grelier, Sarah Mould, Carole Barin, Agnès Daudignon, Nathalie Gachard, Stéphanie Struski, Cathérine Henry, Dominique Penther, Hossein Mossafa, Joris Andrieux, Virginie Éclache, C Bilhou-Nabéra, Isabelle Luquet, Christine Terré, Laurence Baranger, Francine Mugneret, Jean Chiésa, Julien Mozziconacci, Evelyne Callet‐Bauchu, Lauren Véronèse, Hélène Blons, R. G. Owen, Julie Lejeune, Sylvie Chevret, Hélène Merle‐Béral, V. Leblond,

Chronic Myeloid Leukemia Treatments

Waldenström's macroglobulinemia is a disease of mature B cells, the genetic basis of which is poorly understood. Few recurrent chromosomal abnormalities have been reported, and their prognostic value is not known. We conducted a prospective cytogenetic study of Waldenström's macroglobulinemia and examined the prognostic value of chromosomal aberrations in an international randomized trial. The main aberrations were 6q deletions (30%), trisomy 18 (15%), 13q deletions (13%), 17p (TP53) deletions (8%), trisomy 4 (8%), and 11q (ATM) deletions (7%). There was a significant association between trisomy of chromosome 4 and trisomy of chromosome 18. Translocations involving the IGH genes were rare (