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Combination of Microwave Assisted Micellar Extraction and Liquid Chromatography for Determination of Cryptotanshinone, Tanshinone I, and Tanshinone IIA in Salvia Miltiorrhiza Bunge

2009; Taylor & Francis; Volume: 32; Issue: 5 Linguagem: Inglês

10.1080/10826070802711170

1520-572X

Zhihong Shi, Yu Wang, Hongyi Zhang,

Chromatography in Natural Products

Abstract A new method based on the microwave assisted micellar extraction technique (MAME) has been optimized for the extraction of tanshinones from the traditional Chinese medicine-Salvia miltiorrhiza Bunge. Non-ionic surfactant Genapol X-080 solution was employed as extractant. Under optimum conditions, i.e., 10% Genapol X-080 (w/v), liquid/solid ratio 80:1 (mL · g−1), microwave assisted extraction time 7 min (4 min + 3 min), microwave power 260 W, particle size of Salvia miltiorrhiza Bunge <105 µm, the extraction efficiency of tanshinones reached the highest value. Compared with static extraction and ultrasonic assisted extraction techniques, MAME has the highest extraction yield of tanshinones and shortest extraction time. Furthermore, MAME has similar extraction efficiency with the heating reflux method recommended by Chinese Pharmacopoeia.