Produção Nacional
Revisado por pares
Duodenal Ulcer and Eradication of Helicobacter pylori in a Developing Country An 18-Month Follow-up Study
1992; Taylor & Francis; Volume: 27; Issue: 5 Linguagem: Inglês
10.3109/00365529209000088
ISSN1502-7708
AutoresLuiz Gonzaga Vaz Coelho, Magna Cottini Fonseca Passos, Y. Chausson, Evandro Luis de Oliveira Costa, Annubia Freitas Maia, M. J. C. C. Brandao, D. C. Rodrigues, Lúcia Porto Fonseca de Castro,
Tópico(s)Veterinary medicine and infectious diseases
ResumoAbstractForty-eight patients with endoscopically proven duodenal ulcer (DU) and Helicobacter pylori infection detected by 14C-urea breath test (BT) were assigned to 5 days of treatment with furazolidone, metronidazole, and amoxicillin in addition to eventual classical anti-ulcer agents if necessary. Clinical evaluation and BT were repeated at 2, 6, and 18 months after therapy to determine H. pylori eradication or reinfection. Endoscopy was also repeated at 6 and 18 months after treatment to detect DU relapse. In 29 (60%) patients H. pylori had been eradicated at 2 months after therapy, and in 19 (40%) infection persisted. After successful eradication, 6 of 29 (20.7%) were reinfected. All 24 patients who were negative at the 18-month evaluation were asymptomatic, free of anti-ulcer drugs, and with healed ulcers, whereas among the 19 positive patients followed up, 11 (57%) continued to be symptomatic and still using anti-ulcer agents (p < 0.010), and 10 (53%) showed active ulcers at endoscopy (p < 0.010). H. pylori eradication is clearly followed by long-term remission of DU. Reinfection may be an additional problem in treating DU patients in developing countries.Key Words: Amoxicillinantibioticsbreath testduodenal ulcerfurazolidoneHelicobacter pylorimetronidazole
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