SelSim: a program to simulate population genetic data with natural selection and recombination
2004; Oxford University Press; Volume: 20; Issue: 18 Linguagem: Inglês
10.1093/bioinformatics/bth417
ISSN1367-4811
AutoresChris C. A. Spencer, Graham Coop,
Tópico(s)Plant and animal studies
ResumoSelSim is a program for Monte Carlo simulation of DNA polymorphism data for a recombining region within which a single bi-allelic site has experienced natural selection. SelSim allows simulation from either a fully stochastic model of, or deterministic approximations to, natural selection within a coalescent framework. A number of different mutation models are available for simulating surrounding neutral variation. The package enables a detailed exploration of the effects of different models and strengths of selection on patterns of diversity. This provides a tool for the statistical analysis of both empirical data and methods designed to detect natural selection.http://www.stats.ox.ac.uk/mathgen/software.html.http://www.stats.ox.ac.uk/mathgen/software.html.
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