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Design, Synthesis, and SAR Studies of Mefloquine‐Based Ligands as Potential Antituberculosis Agents

2006; Wiley; Volume: 1; Issue: 6 Linguagem: Inglês

10.1002/cmdc.200600010

1860-7187

Sarva Jayaprakash, Yasuyoshi Iso, Baojie Wan, Scott G. Franzblau, Alan P. Kozikowski,

Synthesis and biological activity

Potential new tuberculosis treatment: Mefloquine (1), an antimalarial drug with simple, yet interesting structural features has been found to be active against Mycobacterium tuberculosis. Thus, this molecule is a good candidate as a lead compound in the search for new TB drugs. The design and synthesis of mefloquine analogues is described, and biological data against the TB organism are also presented. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2006/z600010_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.