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BIBTEX RIS

Tumor Vasculature Is Regulated by PHD2-Mediated Angiogenesis and Bone Marrow-Derived Cell Recruitment

2009; Cell Press; Volume: 15; Issue: 6 Linguagem: Inglês

10.1016/j.ccr.2009.04.010

ISSN

1878-3686

Autores

Denise A. Chan, Tiara L.A. Kawahara, Patrick D. Sutphin, Howard Y. Chang, Jen‐Tsan Chi, Amato J. Giaccia,

Tópico(s)

Cancer, Lipids, and Metabolism

Resumo

Sustained angiogenesis, through either local sprouting (angiogenesis) or the recruitment of bone marrow-derived cells (BMDCs) (vasculogenesis), is essential to the development of a tumor. How BMDCs are recruited to the tumor and their contribution to the tumor vasculature is poorly understood. Here, we demonstrate that both IL-8 and angiogenin contribute to the complementary pathways of angiogenesis and BMDC mobilization to increase tumor growth. These two factors are regulated by PHD2 in a HIF-independent but NF-κB-dependent manner. PHD2 levels are decreased in human cancers, compared with corresponding normal tissue, and correlate with an increase in mature blood vessels. Thus, PHD2 plays a critical role in regulating tumor angiogenesis.

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