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Neuroleptics, Lithium and Renal Function

1985; Cambridge University Press; Volume: 146; Issue: 5 Linguagem: Inglês

10.1192/bjp.146.5.510

1472-1465

Derek G. Waller, J. Guy Edwards, Anna Polak,

Electrolyte and hormonal disorders

Renal function test results in 26 patients on neuroleptic treatment, who had never received lithium or antidepressants, were compared with those in a matched group, treated with lithium; also, their tubular response to DDAVP was compared with that of 25 control subjects. Measurements of serum creatinine, creatinine clearance, and urinary albumin excretion showed no abnormality attributable to either neuroleptics or lithium. The maximum urine concentrating ability after DDAVP was significantly lower in the neuroleptic group than in controls, but significantly higher than in the lithium-treated patients. There was a significant correlation between excretion of urinary beta 2-microglobulin and duration of neuroleptic treatment, but mean excretion rates were the same in both treatment groups. The results suggest that neuroleptics as well as lithium impair urine concentrating ability.